期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 24, 页码 7434-7439出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.10.004
关键词
Brachystemma calycinum; Caryophyllaceae; Cyclic peptides; Cytokines; Collagen IV; ROS
资金
- National Natural Science Foundation of China [30700059]
- Talent Scholarship of Yunnan Youth [2007PY01-48]
- Chinese Academy of Sciences [KSCX2-EW-R-15]
Three new cyclic peptides, namely duanbanhuains A-C (1-3), were isolated from the roots of Brachystemma calycinum which is a traditional medicine used to treat rheumatic diseases. Their structures were identified by means of a suite of MS and NMR experiments. These compounds were purposely evaluated for their inhibitory effects on the release of MCP-1, IL-6, collagen IV and reactive oxygen species (ROS) against high-glucose-stimulated mesangial cells. The results showed that compounds 1 and 2 exhibited potent inhibition on the production of IL-6, collagen IV and ROS at the concentration of 10 mu M. (C) 2011 Elsevier Ltd. All rights reserved.
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