期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 13, 页码 3866-3870出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.05.043
关键词
Enzyme; Flavonoid; Rhamnetin; Poplar; O-Methyltransferase; Apoptosis
资金
- Ministry of Education, Science and Technology [2009-0093824]
- Agenda program (RDA) [8-21-52]
- Disease Network Research Program (NRF) [20090084183]
- MEST [2010-0020966]
- National Research Foundation of Korea [2010-0020966] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
To produce rhamnetin using enzymatic engineering, poplar O-methyltransferase-7 and its mutants were prepared based on the rational enzyme design, and the production of rhamnetin was compared with the results obtained using the wild type enzyme. In addition, the potential of using rhamnetin as a cancer chemopreventive agent was compared with that of quercetin in MDA-MB-231 human breast cancer cells, and their bioavailabilities were tested in Dulbecco's modified Eagle's medium. (C) 2011 Elsevier Ltd. All rights reserved.
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