期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 35, 期 8, 页码 1224-1232出版社
SAGE PUBLICATIONS INC
DOI: 10.1038/jcbfm.2015.138
关键词
brain imaging; functional imaging; imaging in awake-moving animal; neurovascular imaging; wearable photoacoustic tomography
资金
- Department of Defense
- J. Crayton Pruitt Family Endowment
- B.J. and Eve Wilder Center of Excellence for Epilepsy Research
We present a noninvasive method of photoacoustic tomography (PAT) for imaging cerebral hemodynamics in awake-moving rats. The wearable PAT (wPAT) system has a size of 15mm in height and 33mm in diameter, and a weight of similar to 8 g (excluding cabling). The wPAT achieved an imaging rate of 3.33 frames/s with a lateral resolution of 243 mu m. Animal experiments were designed to show wPAT feasibility for imaging cerebral hemodynamics on awake-moving animals. Results showed that the cerebral oxyhemoglobin and deoxy-hemoglobin changed significantly in response to hyperoxia; and, after the injection of pentylenetetrazol (PTZ), cerebral blood volume changed faster over time and larger in amplitude for rats in awake-moving state compared with rats under anesthesia. By providing a light-weight, high-resolution technology for in vivo monitoring of cerebral hemodynamics in awake-behaving animals, it will be possible to develop a comprehensive understanding on how activity alters hemodynamics in normal and diseased states.
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