Design and efficient synthesis of A-278637 derivatives as potential potassium channel opener

A series of thieno[3,2-b] quinoline derivatives designed based on A-278637 scaffold, were synthesized efficiently via one-pot three-component reaction under solvent-free and catalyst-free conditions. This work provides a new compound library with potential biological activity for biomedical screening. (c) 2010 Elsevier Ltd. All rights reserved.