Synthesis and antidyslipidemic activity of chalcone fibrates

A series of chalcone based PPAR-alpha agonists were synthesized and evaluated for their antidyslipidemic activity in high fructose high fat fed dyslipidemic Syrian golden hamsters. Most of the compounds exhibited antidyslipidemic activity. The compounds 4c and 4f have been identified as most potent antidyslipidemics. A definite structure-activity relationship was observed while varying the nature as well as the position of the substituent. (C) 2011 Elsevier Ltd. All rights reserved.