期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 3, 页码 809-813出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.12.102
关键词
Pyrano[3,2-c]pyridone; Pyrano[4,3-b]pyran; Pyrimidine nucleoside; Hybrid compounds; Ionic liquids; Antivirals; Antileishmanial agents
资金
- National Natural Science Foundation of China [20772025, 20972042, 20911140238]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [2008HASTIT006]
- Natural Science Foundation of Henan Province [092300410192, 094300510054]
A highly practical and efficient preparation of pyrano[3,2-c]pyridone and pyrano[4,3-b]pyran derivatives was developed via an ionic liquid mediated and promoted multi-component reaction of aldehyde (1), 4-hydroxy-pyridin-2(1H)-one or 4-hydroxy-2-pyranone (2), and malononitrile (3). As an application, a series of pyrimidine nucleoside-pyrano[3,2-c]pyridone or pyrano[4,3-b]pyran hybrids were efficiently obtained. These hybrid compounds were evaluated as potential antiviral and antileishmanial agents and showed encouraging biological activities. (C) 2009 Elsevier Ltd. All rights reserved.
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