期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 6, 页码 1881-1884出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.01.159
关键词
Carbazole; Imidazole; 1,2,4-Triazole; Triazolium; Antibacterial; Antifungal
资金
- Natural Science Foundation of Chongqing [CSCT: 2007BB5369]
- Southwest University [SWUB2006018, XSGX0602]
A series of N-substituted carbazole derivatives were synthesized and evaluated for antibacterial and antifungal activities against Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, Bacillus proteus, Candida albicans and Aspergillus fumigatus by two fold serial dilution technique. Some of the synthesized compounds displayed comparable or even better antibacterial and antifungal activities than reference drugs fluconazole, chloramphenicol and norfloxacin against tested strains. (C) 2010 Elsevier Ltd. All rights reserved.
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