期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 66, 页码 9521-9524出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/d0cc03789c
关键词
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资金
- National Natural Science Foundation of China [21571143]
- Shandong Provincial Natural Science Foundation of China [ZR2017MB029, ZR2017BB060]
- Qingdao Science and Technology Foundation [18-2-2-49-jch]
A practical and efficient base mediated synthesis of free 3-aminoindazoles has been developed from the reaction of nitriles with hydrazines, which successfully overcomes the difficulty of using aromatic hydrazines as substrates and allows for the synthesis of a wide range ofN-aryl substituted free 3-aminoindazoles in moderate to excellent yields under mild conditions in one-pot. This finding provides a rapid and useful strategy for the synthesis of various functionalized 3-aminoindazole derivatives.
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