期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 15, 页码 4602-4606出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.06.012
关键词
T-type calcium channel (Ca(V)3.2); Spiro-azetidines; Spiro-azetidinones; Neuropathic pain
A series of spiro-azetidines and azetidinones has been evaluated as novel blockers of the T-type calcium channel (Ca(V)3.2) which is a new therapeutic target for the potential treatment of both inflammatory and neuropathic pain. Confirmation and optimization of the potency, selectivity and DMPK properties of leads will be described. (C) 2010 Elsevier Ltd. All rights reserved.
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