期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 7, 页码 2299-2302出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.01.160
关键词
Fc epsilon RI; Epigallocatechin gallate; Delphinidin; Tricetinidin; Human mast cell; Anti-allergy
资金
- San-Ei Gen F. F. I. Inc.
- Chamber of Tea Association of Shizuoka Prefecture
Exploration for inhibitors against expression of IgE receptor (Fc epsilon RI) on human mast cell, a significant trigger to acute and chronic allergic symptoms, disclosed epigallocatechin gallate (EGCG), epicatechin gallate, and gallocatechin gallate as active principles. Additionally, the anthocyanidin, delphinidin, and the flavone, tricetinidin, possessing a pyrogallol function were also revealed to suppress expression of FceRI. Structure-activity relationship analysis among catechins, anthocyanidins, and flavones revealed the pyrogallol moiety to be crucial for biological potency. Furthermore, EGCG was clarified to reduce generation of gamma-chain subunit to suppress expression of FceRI on human mast cells. (C) 2010 Elsevier Ltd. All rights reserved.
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