期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 9, 页码 2713-2717出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.03.080
关键词
Ristocetin; Glycopeptide antibiotic; Antibacterial; Anti-influenza virus; Click reaction
资金
- Hungarian Research Fund [79126, T-46186, CK 77515, NK 68578]
- Flemish Fonds voor Wetenschappelijk Onderzoek (FWO) [9.0188.07]
- International Consortium for Anti-Virals (ICAV)
New sugar derivatives of ristocetin were prepared by copper-catalyzed 1,3-dipolar cycloaddition reaction using azido-ristocetin aglycon and various propargyl glycosides. Some of them were found to be active against Gram-positive bacteria and showed favorable antiviral activity against the H1N1 subtype of influenza A virus. (C) 2010 Elsevier Ltd. All rights reserved.
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