Substituted spiro [2.3′] oxindolespiro [3.2]-5,6-dimethoxy-indane-1-one-pyrrolidine analogue as inhibitors of acetylcholinesterase

Series of pyrolidine analogues were synthesized and examined as acetylcholinesterase (AChE) inhibitors. Among the compounds, compounds 4k and 6k were the most potent inhibitors of the series. Compound 4k, showed potent inhibitory activity against acetyl cholinesterase enzyme with IC(50) 0.10 mu mol/L. Pyrolidine analogues might be potential acetyl cholinesterase agents for AD. (C) 2010 Elsevier Ltd. All rights reserved.