4.7 Article

Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment

期刊

CHEMICAL COMMUNICATIONS
卷 56, 期 29, 页码 4098-4101

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09598e

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资金

  1. NIH [NIBIB: P41 EB020594, NCI: P30 CA168524, R01 CA211720, NIGMS: P20 GM130423, P20GM103638]
  2. KU Endowment Funds [DOD-47040-2974000-908]

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We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400-450 nm). The PC linker allowed rapid (2 min) and efficient (>90%) release of CTCs and EVs without damaging their molecular cargo.

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