期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 20, 页码 6024-6029出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.08.065
关键词
Plasmodium falciparum; Malaria; Triazenes
资金
- Victorian State Government
- NHMRC [361646]
- Alan Harris Fellowship
We report on the discovery of 3-alkylthio-1,2,4-triazine dimers that are potently toxic to Plasmodium falciparum, with single digit nanomolar activity, and up to several thousand-fold lower toxicity to mammalian cells. They are equipotent against chloroquine-resistant strains of P. falciparum. (c) 2010 Elsevier Ltd. All rights reserved.
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