期刊
CHEMICAL COMMUNICATIONS
卷 56, 期 20, 页码 3039-3042出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c9cc09098c
关键词
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资金
- Dutch Research Council (NWO, NCI-TA grant) [731.015.202]
- European Research Council (ERC) [ChemEpigen-715691]
We report synthesis and enzymatic assays on human histone lysine methyltransferase catalysed methylation of histones that possess lysine and its geometrically constrained analogues containing rigid (E)-alkene (K-E), (Z)-alkene (K-Z) and alkyne (K-yne) moieties. Methyltransferases G9a and GLP do have a capacity to catalyse methylation in the order K >> K-E > K-Z similar to K-yne, whereas monomethyltransferase SETD8 catalyses only methylation of K and K-E.
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