期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 7, 页码 2111-2114出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.02.059
关键词
Androgen; Antagonist; Essential oil; CoMFA; Drug design
资金
- Ministry of Education, Science and Culture, Japan
The effect of essential oils, such as raspberry ketone, on androgen (AR) receptor was investigated using a MDA-kb2 human breast cancer cell line for predicting potential AR activity. Among them, eugenol had the highest AR antagonistic activity with its IC50 value of 19 mu M. Raspberry ketone, which has threefold higher anti-obese activity than that of capsaicin, also had AR antagonist activity with its IC50 value of 252 mu M. Based on these findings, a more precise CoMFA model was proposed as follows: pIC(50) [log (1/IC50)] = 3.77 + [CoMFA field terms] (n = 39, s = 0.249, r(2) = 0.834, s(cv) = 0.507, q(2) = 0.311 (three components). (C) 2010 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据