期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 3, 页码 1059-1062出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.12.031
关键词
p38; Piperidine; Heterocyclic; MAP; Kinase; Inhibitor; Oxalyl; Amide; Inflammatory
The design and synthesis of a new class of p38 alpha MAP kinase inhibitors based on 4-fluorobenzylpiperidine heterocyclic oxalyl amides are described. Many of these compounds showed low-nanomolar activities in p38 alpha enzymatic and cell-based cytokine TNF alpha production inhibition assays. The optimal linkers between the piperidine and the oxalyl amide were found to be [6,5] fused ring heterocycles. Substituted indoles and azaindoles were favored structural motifs in the cellular assay. (C) 2009 Elsevier Ltd. All rights reserved.
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