期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 5, 页码 1598-1600出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.01.084
关键词
HCV; Envelope protein E1, E2; Rosa rugosa Thunb.; Tellimagrandin I; Invasion inhibitor
资金
- Ministry of Education, Science, Culture and Sports, and Research
- Kampou Science Foundation
By use of the model virus, expressing the HCV envelope proteins E1 and E2, bioassay guided separation of the MeOH extract from Rosa rugosa Thunb. disclosed tellimagrandin I (1) together with eugeniin (2) and casuarictin (3) as the potent HCV invasion inhibitors. Furthermore, structure-activity relationship analysis of some relative tannins including the synthesized analogs elucidated the partial structures crucial for potent activity of 1. (C) 2010 Elsevier Ltd. All rights reserved.
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