期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 22, 页码 6542-6546出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.09.036
关键词
Cyclosporin; Cyclophilin; Hepatitis C
An efficient synthesis of [D-lysine](8)cyclosporin A has been developed. Several analogs of [ D- lysine] 8cyclosporin A have been synthesized and show promising anti-HCV activity, particularly compounds 39 and 43, which each exhibit an anti-HCV EC50 < 200 nM, and are each >= 50-fold less immunosuppressive than cyclosporin A. (C) 2010 Elsevier Ltd. All rights reserved.
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