期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 18, 页码 5544-5547出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.07.060
关键词
Calcimimetic; Allosteric modulator
The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model. (C) 2010 Elsevier Ltd. All rights reserved.
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