Substituted biaryl pyrazoles as sodium channel blockers

Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. A series of low molecular weight biaryl substituted pyrazole carboxamides were identified with good in-vitro potency and in-vivo efficacy. Compound 26, a Na(v)1.7 blocker has excellent efficacy in the Chung model of neuropathic pain. (c) 2010 Elsevier Ltd. All rights reserved.