期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 18, 页码 5567-5571出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.07.021
关键词
Depression; Antidepressant; Serotonin; Norepinephrine; Dopamine; Reuptake; Inhibitor
资金
- Korea Health Industry Development Institute (KHIDI)
A series of 3-aryl-3-azolylpropan-1-amines was prepared and screened for its capability of inhibiting monoamine reuptake. Analogs with nanomolar potency, good human in vitro microsomal stability, and low drug-drug interaction potential were described. In vivo models were used to evaluate the compound 19r for antidepressive, anxiolytic, and analgesic activity. (C) 2010 Elsevier Ltd. All rights reserved.
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