Substituted biaryl oxazoles, imidazoles, and thiazoles as sodium channel blockers

Voltage-gated sodium channels have been shown to play a critical role in neuropathic pain. With a goal to develop potent peripherally active sodium channel blockers, a series of low molecular weight biaryl substituted imidazoles, oxazoles, and thiazole carboxamides were identified with good in vitro and in vivo potency. (C) 2010 Elsevier Ltd. All rights reserved.