期刊
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
卷 35, 期 3, 页码 363-366出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/jcbfm.2014.235
关键词
beta-amyloid; calcium; cell therapy; cerebral ischemia; secondary pathology
资金
- Health Research Council of the Academy of Finland
This study examined whether human bone marrow mesenchymal stromal/stem cells (BMMSCs) could alleviate the secondary pathology in the thalamus after middle cerebral artery occlusion. (MCAO) in rats. Atypical accumulation of both amyloid-beta (A beta) and calcium in the thalamus was significantly higher in rats receiving the BMMSCs infusion 48 hours after MCAO as compared with the vehicle MCAO group. The elevated A beta/calcium accumulation correlated with the level of impaired sensorimotor function. Although secondary pathology in the thalamus seems to be rodent specific, it needs to be taken into account because it may impair long-term behavioral recovery and negate therapeutic treatment effects.
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