期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 8, 页码 2493-2496出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.03.005
关键词
Kv1.5; TAEA; Triarylethanolamine; Arrhythmia; Atrial fibrillation
A series of triarylethanolamine inhibitors of the Kv1.5 potassium channel have been prepared and evaluated for their effects in vitro and in vivo. The structure-activity relationship (SAR) studies described herein led to the development of potent, selective and orally active inhibitors of Kv1.5. (C) 2010 Elsevier Ltd. All rights reserved.
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