4.5 Article

Solubilization and deaggregation of cobalt bis(dicarbollide) derivatives in water by biocompatible excipients

期刊

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 3, 页码 1045-1048

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.12.038

关键词

Cobalt bis(dicarbollide); Metallacarborane; Excipient; Solubilization; Deaggregation; Cyclodextrin; Surfactant

资金

  1. Ministry of Education, Youth and Sports of the Czech Republic [LC512]
  2. Czech Republic [203/09/1311]
  3. Czech Academy of Science [KAN200100801]

向作者/读者索取更多资源

In the field of medicinal chemistry, cobalt bis(dicarbollide) derivatives are promising therapeutic agents. The potential pharmaceutical utilization of metallacarboranes is complicated due to spontaneous self-assembling in water. This problem can be solved by using suitable deaggregating agent. We present here the comprehensive screen of substituted cobalt bis(dicarbollide) derivatives with cyclodextrin derivatives, classical surfactants and amphiphilic copolymers to find general biocompatible excipients. Preliminary results are obtained by using UV/Vis spectroscopy as the technique with the best ratio of applicable information to time and source dependence. (C) 2009 Elsevier Ltd. All rights reserved.

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