期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 1, 页码 189-192出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.10.139
关键词
HIV; Gp41; Inhibitor
资金
- GeometryLifeSci, LLC
- NIH [AI46221]
- National Science Foundation of China [20942001]
- New Investigators from Guangzhou Institute of Biomedicine and Health (GIBH)
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI046221, R21AI046221] Funding Source: NIH RePORTER
A new series of N-carboxyphenylpyrrole ligands were designed using GeometryFit based on an X-ray crystal structure of gp41. The synthesized ligands showed significant inhibitory activities against HIV gp41 6-helix bundle formation, HIV-1 mediated cell-cell fusion and HIV-1 replication. (C) 2009 Elsevier Ltd. All rights reserved.
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