期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 4, 页码 1360-1362出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.01.004
关键词
N-Methylated; Peptides; Amylin; Cytotoxicity
资金
- National Research Foundation (NRF), South Africa
- NRF and Aspen Pharmcare (SA)
The incidence of type II diabetes is on the increase each year and the World Health Organisation (WHO) predicts there to be over 360 million diabetic patients worldwide by the year 2030. Deposits consisting mainly of a small protein, called islet amyloid polypeptide (amylin), which aggregates into oligo-/polymeric beta sheet structures is responsible for cytoxicity to the pancreatic beta-cells, thus inhibition of this process has been explored as a potential prevention or treatment. N-Methylated and non N-methylated peptides spanning the length of amylin(1-37) were synthesised and evaluated for their inhibition of full length amylin mediated cytoxicity to RIN-5F cells. The non N-methylated peptides were very effective in inhibiting the cytotoxicity while the N-methylated peptides were not. Both the N-methylated and non N-methylated versions of the 29-34 region were equally effective. (C) 2010 Elsevier Ltd. All rights reserved.
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