期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 20, 期 18, 页码 5431-5433出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2010.07.105
关键词
Carbene; C-H Insertion; Serotonin; 5-HT2C; 5-HT6; 1,2,3,4,10,10a-Hexahydro-pyrazino[1,2-a]indole
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular CH insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands. (c) 2010 Elsevier Ltd. All rights reserved.
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