期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 3, 页码 706-709出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.12.041
关键词
Curcumin; DNA hypomethylation agent
资金
- NIH-NCI [RO1 CA102031]
- BioMedical Mass Spectrometry Laboratory, College of Pharmacy
Molecular docking of the interaction of curcumin and DNMT1 suggested that curcumin covalently blocks the catalytic thiolate of C1226 of DNMT1 to exert its inhibitory effect. This was validated by showing that curcumin inhibits the activity of M. SssI with an IC50 of 30 nM, but no inhibitory activity of hexahydrocurcumin up to 100 mu M. In addition, curcumin can induce global DNA hypomethylation in a leukemia cell line. Published by Elsevier Ltd.
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