期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 14, 页码 3895-3898出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.097
关键词
Henry reaction; Nitroaldol reaction; Guanidine; Organocatalysis; Asymmetric catalysis
资金
- Ministry of Education, Culture, Sports, Science and Technology, Japan [19020006]
- JSPS
- Grants-in-Aid for Scientific Research [19020006] Funding Source: KAKEN
The enantioselective activation of nitroalkanes was attempted on the basis of the complexation between chiral guanidinium and nitronate through two hydrogen bonds. The proposed enantioselective activation was applied to the diastereo- and enantioselective Henry (nitroaldol) reaction of nitroalkanes with aldehydes using axially chiral guanidine bases as the catalyst. Optically active nitroaldol products were obtained in acceptable yields with fairly good enantio- and diastereoselectivities at low temperature. (C) 2009 Elsevier Ltd. All rights reserved.
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