期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 6, 页码 1572-1574出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.02.025
关键词
Ginkgo biloba; Endophytic fungus; Chaetomium globosum; Chaetomugilin D; Azaphilones; Toxic activity
资金
- National Natural Science Foundation of China [30430020]
- Program for New Century Excellent Talents in University [NCET-05-0852]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT0749]
- National Financial Aid for Studying Abroad [2007103088]
A novel cytotoxic chlorinated azaphilone derivative named chaetomugilin D (1), together with three known metabolites, chaetomugilin A (2), chaetoglobosins A (3) and C (4), has been isolated by a bioassay-guided fractionation from the EtOAc extract of the cultures of Chaetomium globosum, an endophytic fungus found in the leaves of Ginkgo biloba. Structure of 1 was established by analyses of spectroscopic methods, including 2D-NMR experiments (COSY, NOESY, HMQC, and HMBC). Compounds 1-4 displayed significant growth inhibitory activity against the brine shrimp (Artemia salina) and Mucor miehei. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.
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