期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 16, 页码 4786-4789出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.06.049
关键词
Isatin; 3,3-diindolyl and dipyrrolyl oxindoles; Iodine; Spermicidal potential; Transmission electron microscopy
Syntheses of 3,3-diheteroaromatic oxindole derivatives has been achieved by coupling indole-2,3-dione (isatin) with differently substituted indoles and pyrrole in presence of I-2 in i-PrOH. The in vitro spermicidal potentials and the mode of spermicidal action of the synthesized analogues were evaluated and the derivative, 3,3-bis (5-methoxy-1H-indol-3-yl) indolin-2-one (3d) exhibited most significant activity. (C) 2009 Elsevier Ltd. All rights reserved.
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