期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 14, 页码 3934-3937出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.112
关键词
Asymmetric catalysis; Organocatalysis; Proline; Kinetics; Mechanism
资金
- EPSRC
- Royal Society Wolfson Research Merit Award
Reaction progress kinetic analysis of the proline-mediated intermolecular aldol reaction shows that the rate depends on the concentrations of both the donor ketone1 and the electrophilic aldehyde 2, implying that enamine formation cannot be rate-determining. The observed kinetics and deuterium isotope effects are consistent with formation of the product iminium species as the rate-determining step. (C) 2009 Elsevier Ltd. All rights reserved.
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