期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 14, 页码 3825-3827出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.040
关键词
Wnt; Inhibitor; SAR; IWR
资金
- UT Southwestern Medical Center
- NIH [NCI P01CA095471, NIGMS R01-GM079554, NIGMS R01-GM076398]
- American Cancer Society [RSG GMC-112251]
- Welch Foundation [I-1596, I-1665]
Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds. (C) 2009 Elsevier Ltd. All rights reserved.
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