期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 24, 页码 6911-6913出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.10.080
关键词
Boron dipyrromethenes; Fluorescence; Protein labeling
资金
- National Institute of Health [R01 CA69571]
- Research Foundation of the State University of New York
Sulfur-containing 3,5-disubstituted boron dipyrromethene (Bodipy (R)) fluorescent probes with improved water solubility were synthesized. A dicarboxylic acid derivative that can be excited by the 543 nm HeNe laser line is very soluble in aqueous solution and retains high fluorescence quantum yield of the unionizable parent molecule. Conversion of the dicarboxylic acid to the succimidyl or sulfosuccinimidyl diester produces molecules capable of labeling proteins with a bright and stable fluorescence signal. (C) 2009 Elsevier Ltd. All rights reserved.
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