期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 4, 页码 1118-1121出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2008.12.108
关键词
Caffeic acid; Cinnamic acid; 5-Lipoxygenase inhibitors; Clusters; Triazole
资金
- New Brunswick Innovation Foundation
- Medical Research Fund
- Canada Research Chairs Program
Novel cinnamoyl and caffeoyl clusters were synthesized by multiple Cu(I)-catalyzed [1,3]-dipolar cycloadditions and their anti-5-lipoxygenase inhibitory activity was tested. Caffeoyl cluster showed an improved 5-lipoxygenase inhibitory activity compared to caffeic acid, with caffeoyl trimer 16 and tetramer 19 showing the best 5-lipoxygenase inhibitory activity. (C) 2008 Elsevier Ltd. All rights reserved.
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