期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 8, 页码 2129-2132出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.03.007
关键词
Anti-inflammatory; Phosphodiesterase; Oxaborole; Psoriasis; Atopic dermatitis
A series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. This compound is now in clinical development for the topical treatment of psoriasis and being pursued for the topical treatment of atopic dermatitis. (C) 2009 Elsevier Ltd. All rights reserved.
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