期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 11, 页码 2960-2964出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.04.052
关键词
Hexahydroindazoles; Antibacterial; Antifungal; QSAR
资金
- All India Council of Technical Education, New Delhi, India
Antimicrobial activity of synthesized 2,3-disubstituted-3,3a,4,5,6,7-hexahydro-2H-indazole derivatives indicated that 3-(4-chlorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a, 4,5,6,7-hexahydro-2H-indazole (6) and 3-(4-fluorophenyl)-2-(4-nitrophenylsulfonyl)-3,3a, 4,5,6,7-hexahydro-2H-indazole (20) were the most active compounds. Further, the results of QSAR studies indicated the importance of topological parameters (2)chi and (2)chi(v) in defining the antimicrobial activity of hexahydroindazoles. (C) 2009 Elsevier Ltd. All rights reserved.
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