期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 21, 页码 6009-6013出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.062
关键词
Reactive oxygen species; Antioxidant; Ischemia; Quercetin 3-O-methyl ether; Glucose; Neuroprotection
资金
- Plant Diversity Research Center of the 21st Century Frontier Research Program [PF06216-00]
Due to high reactivity, reactive oxygen species can attack biological molecules leading to cell or tissue injury. In this study, glucose moiety was attached at the C-7 position of quercetin 3-O-methyl ether (1) and luteolin (2) through glycosidic bond or ether linkage. The glucose-containing compounds showed potent DPPH and superoxide anion radical scavenging and lipid peroxidation inhibition activities and nearly equivalent protective actions to the parent aglycons against the H2O2-induced oxidative neuronal damage in primary cultured rat cortical cells. Among the compounds tested, 3b and 3c were the most potent (IC50 values = 7.33 and 5.34 mu M, respectively), exhibiting nearly equivalent actions to the parent compounds 1 and 2 (IC50 = 3.50 and 3.75 mu M, respectively). (C) 2009 Elsevier Ltd. All rights reserved.
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