期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 15, 页码 4097-4101出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.06.011
关键词
Dipeptidyl peptidase-IV; DPP-4; DPP-IV; Dipeptidyl peptidase 8; DPP-8; DPP-9; Quiescient peptidyl peptidase; QPP; GLP-1; Glucagon-like peptide 1; Benzimidazole; Imidazopyridine; Buchwald coupling; Sitagliptin
资金
- Center for Advanced Radiation Sources at the University of Chicago
- U. S. Department of Energy, Office of Science, Office of Basic Energy Sciences [W-31-109-Eng-38]
- Offices of Biological and Environmental Research and of Basic Energy Sciences of the US Department of Energy
- National Center for Research Resources of the National Institutes of Health
A new series of DPP-4 inhibitors derived from piperidine-fused benzimidazoles and imidazopyridines is described. Optimization of this class of DPP-4 inhibitors led to the discovery of imidazopyridine 34. The potency, selectivity, cross-species DMPK profiles, and in vivo efficacy of 34 is reported. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据
分享论文
