期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 15, 页码 4139-4142出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.06.003
关键词
Bisintercalator; Dinuclear Iron(III) complex; Artificial nuclease
资金
- Ministry of Education of China [707016]
- National Natural Science Foundation of China [20706008, 20725621]
Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage. (C) 2009 Elsevier Ltd. All rights reserved.
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