4.5 Article

Bisintercalator-containing dinuclear iron(III) complex: An efficient artificial nuclease

期刊

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 15, 页码 4139-4142

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.06.003

关键词

Bisintercalator; Dinuclear Iron(III) complex; Artificial nuclease

资金

  1. Ministry of Education of China [707016]
  2. National Natural Science Foundation of China [20706008, 20725621]

向作者/读者索取更多资源

Two acridine groups were successfully introduced into di-iron(III) complex. DNA cleavage experiments indicated that complex conjugating bisacridine groups can enhance 300-fold for the cleavage efficiency compared with complex lacking of acridine conjugation. Further ligation assay of DNA segments provided the evidence for hydrolytic mechanism of DNA cleavage. (C) 2009 Elsevier Ltd. All rights reserved.

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