期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 18, 页码 5505-5509出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.05.060
关键词
Combi-triazenes; EGFR; HER2; Quinazoline
资金
- Canadian Institutes of Health Research (CHIR) [FRN 49440]
The monoalkyltriazene moiety lends itself well to the design of combi-molecules. However, due to its instability under physiological conditions, efforts were directed towards stabilizing it by grafting a hydrolysable carbamate onto the 3-position. The synthesis and biological activities of these novel N-carbamyl triazenes are described. (C) 2009 Elsevier Ltd. All rights reserved.
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