期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 22, 页码 6303-6306出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.093
关键词
Anticancer activity; Deoxoartemisinin; Non-acetal type; Antiangiogenesis
资金
- Ministry of Health & Welfare, Republic of Korea [A084166]
- Ministry of Education and Human Resources Development, the Republic of Korea
- Korea Health Promotion Institute [A084166] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Novel amide derivatives of C-12 non-acetal deoxoartemisinin were synthesized. Some of the derivatives had potent in vitro anticancer activity against major human cancer cell lines. The deoxoartemisinin amide trimer had potent in vivo antiangiogenic activity, according to the mouse matrigel plug assay. (C) 2009 Elsevier Ltd. All rights reserved.
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