期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 13, 页码 3386-3388出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.05.042
关键词
Glycolipids; Alpha-galactosyl ceramides; CD1d; iNKT cell stimulation
资金
- NIH NIAID [RO1AI057519, RO1 AI45889]
- Royal Society Wolfson Research Merit Award
- former Lister Institute-Jenner Research Fellow
- Medical Research Council
- Wellcome Trust [084923/B/08/Z]
- Wellcome Trust [084923/B/08/Z] Funding Source: Wellcome Trust
- MRC [G0400421] Funding Source: UKRI
- Medical Research Council [G0400421] Funding Source: researchfish
An alpha-galactosyl ceramide (alpha-GalCer) 2 was synthesized and evaluated for its ability to stimulate iNKTcell proliferation and elicit T-helper cytokines, IL-4 and IFN gamma. Compound 2 combines the acyl chain of the potent, Th2 biasing alpha-GalCer 1 with a sphingoid base of the same length as that found in OCH, which also exhibits Th2 skewing, Such complementation may enhance cytokine bias, which is thought to be important for therapeutic applications of iNKT cell stimulation. Two related alpha-GalCers, 3 and 4, with saturated acyl chains were prepared for comparison. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据