期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 6, 页码 1623-1627出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.02.006
关键词
Platensimycin; Platensimycin analogs; FabF; Inhibition of bacterial type II fatty-acid synthesis
Platensimycin (1) displays antibacterial activity due to its inhibition of the elongation condensing enzyme (FabF), a novel mode of action that could potentially lead to a breakthrough in developing a new generation of antibiotics. The medicinal chemistry efforts were focused on the modi. cation of the enone moiety of platensimycin and several analogs showed significant activity against FabF and possess antibacterial activity. (C) 2009 Published by Elsevier Ltd.
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