期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 23, 页码 6561-6564出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.10.032
关键词
Nucleic acids; Aptamers; Caged compounds
资金
- Deutsche Forschungsgemeinschaft [MA 3442/1-1, MA 3442/1-2]
- Emmy-Noether stipend [HE 4597/1-1]
- Cluster of Excellence Macromolecular Complexes [EXC 115]
- Fonds der Deutschen Chemischen Industrie
- Scottish Universities Life Science Association (SULSA)
Caged aptamers represent valuable tools for the spatiotemporal control of protein function by light. Here we describe a general route starting with the de novo selection process targeting cytohesin-1 and aiming at the synthesis of caged aptamers without the prior knowledge of detailed structural determinants of aptamer-target binding. (C) 2009 Elsevier Ltd. All rights reserved.
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