期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 18, 页码 5334-5338出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.07.135
关键词
Voltage gated sodium channel blocker; Neuropathic pain; Inflammatory pain; Amide replacement; Heterocycles; Isoxazole
A series of novel isoxazole voltage gated sodium channel blockers have been synthesized and evaluated. Substitutions on the benzylic position of benzamide were investigated to determine their effect on Na(v)1.7 inhibitory potency. The spirocyclobutyl substitution had the most significant enhancement on Na(v)1.7 inhibitory activity. (C) 2009 Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据