O-Spiro C-aryl glucosides as novel sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors

Two series of O-spiro C-aryl glucosides were synthesized and tested for inhibition of hSGLT1 and hSGLT2. 60-O-Spiro C-aryl glucosides exhibited potent in vitro hSGLT2 inhibitory activity but 20-O-spiro C-aryl glucosides showed no in vitro hSGLT2 inhibitory activity at a screening concentration of 1 mu M. (C) 2009 Elsevier Ltd. All rights reserved.