期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 19, 期 22, 页码 6280-6283出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2009.09.101
关键词
Thiazolidinone; Pyrimidine nucleoside-thiazolidinone; Hybrids; Ionic liquid; Eco-friendly synthesis; Multi-component reaction; Antiparasitic activities
资金
- National Natural Science Foundation of China [20772025, 20772024]
- Program for Science & Technology Innovation Talents in Universities of Henan Province [2008HASTIT006]
Without any catalyst, 2,3-disubstituted-1,3-thiazolidin-4-one derivatives were synthesized efficiently via the three-component reaction of aldehyde, amine and mercaptoacetic acid in [bmim][PF6]. The whole procedure is simple and straightforward and no aqueous work-up is needed. By employing this protocol, a series of novel pyrimidine nucleoside-thiazolidin-4-one hybrids were prepared and their preliminary antiparasitic activities were also studied and reported. (C) 2009 Elsevier Ltd. All rights reserved.
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